Photodynamic Therapy for Cutibacterium Acnes (C. Acnes) Decolonization of the Shoulder Dermis
Status unconfirmed · Phase 3
Conditions studied: C. Acnes, Phototherapy, Postoperative Infection, Arthroscopic Rotator Cuff Repair, Shoulder Surgery
In brief
This is a prospective, randomized controlled trial to evaluation the ability of 5-aminolevulinic acid HCL topical solution photodynamic therapy to decrease the colonization of Cutibacterium acnes (C. acnes- a bacteria commonly found in the dermis of the skin surrounding the shoulder) in order to decrease postoperative joint infections. -Aminolevulinic acid (ALA) is a naturally occurring metabolite in the synthesis of pathway of cellular heme production. Adding ALA to bacteria encourages porphyrin production which serve as the immediate precursors to heme production. When these porphyrins are illuminated with blue light at an emission peak of 407-420nm, these metabolites become exothermic and cause internal destruction of the bacterial cells. This therapy does not cause any damage to the mammalian cells, which makes PDT safe for human skin treatment.
Key facts
- Study ID
- NCT04636242
- Run by
- Rothman Institute Orthopaedics
- People needed
- 120
- Starts
- 2019-08-22
- Expected to finish
- 2021-08-31
- Last updated by the study team
- 2020-11-19
Who can join
Age: 18 and older, up to 80. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- All male patients (>18) undergoing shoulder arthroscopy)
You may not qualify if…
- Female patients
- Patients with active acnes
- Patients who have taken antibiotics within a month of their surgery
- Subjects with psoriatic/eczematous lesions on the shoulder girdle
- Patients on anticoagulant therapy
- Patients who have a known allergy to any of the agents used in the study protocol
Where it is running
- Rothman Orthopaedic Institute — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.