Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)

Stopped early · Phase 2

Conditions studied: Treatment Resistant Depression, Major Depressive Disorder

In brief

This study is a multi-center, open-label trial to evaluate the long-term safety and efficacy of AXS-05 in subjects with major depressive disorder with prior treatment failures

Key facts

Study ID: NCT04634669
Run by: Axsome Therapeutics, Inc.
People needed: 181
Starts: 2020-09-23
Expected to finish: 2022-03-04
Last updated by the study team: 2026-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Clinical Research Site — Little Rock, Arkansas, United States
Clinical Research Site — Redlands, California, United States
Clinical Research Site — Sherman Oaks, California, United States
Clinical Research Site — Upland, California, United States
Clinical Research Site — Miami, Florida, United States
Clinical Research Site — Miami Lakes, Florida, United States
Clinical Research Site — Orlando, Florida, United States
Clinical Research Site — Chicago, Illinois, United States
Clinical Research Site — Boston, Massachusetts, United States
Clinical Research Site — Berlin, New Jersey, United States
Clinical Research Site — Rochester, New York, United States
Clinical Research Site — Staten Island, New York, United States
Clinical Research Site — Hickory, North Carolina, United States
Clinical Research Site — Raleigh, North Carolina, United States
Clinical Research Site — Cincinnati, Ohio, United States
Clinical Research Site — Middleburg Heights, Ohio, United States
Clinical Research Site — Media, Pennsylvania, United States
Clinical Research Site — Dallas, Texas, United States
Clinical Research Site — Friendswood, Texas, United States
Clinical Research Site — Everett, Washington, United States

Full record on ClinicalTrials.gov

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