Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Recruiting now

Conditions studied: NAFLD

In brief

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Key facts

Study ID

NCT04634643

Run by

Yale University

People needed

260

Starts

2021-06-28

Expected to finish

2027-01-30

Last updated by the study team

2026-07-30

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Good general health, taking no medication on a chronic basis;
• age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
• BMI >85th for obese cohort;

You may not qualify if…

• Baseline creatinine >1.0 mg; pregnancy;
• the presence of endocrinopathies (e.g. Cushing syndrome);
• cardiac or pulmonary or other significant chronic illness;
• adolescents with a psychiatric disorder or with substance abuse;
• monogenic obesity syndromes;
• use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

Where it is running

• Yale New Haven Hospital — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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