Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes

Completed · Not applicable

Conditions studied: Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy

In brief

Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease. Some of the extra risk for heart disease after APOs is thought to be caused by inflammation. Investigators will randomize women who had an APO in the past 3 years to receive an anti-inflammatory supplement or serve as a time control. Investigators will compare blood pressure, arterial stiffness, blood vessel reactivity, and blood markers of inflammation between women who did and did not receive the supplement. Investigators will determine women's attitudes about taking a dietary supplement and measure whether the participants who receive the supplement take all or most of the doses.

Key facts

Study ID: NCT04633551
Run by: University of South Carolina
People needed: 9
Starts: 2020-10-01
Expected to finish: 2022-05-30
Last updated by the study team: 2023-09-21

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Had a singleton pregnancy in the past 3 years that lasted 20 weeks or more
Most recent pregnancy was complicated by an APO

You may not qualify if…

currently pregnant or breastfeeding,
current smoking,
active cancer,
regular use of NSAIDs, steroidal medications, statins, or other anti-inflammatory supplements,
HIV/AIDS,
uncontrolled high blood pressure ( >160/>110 mmHg),
unwilling or unable to use a dietary supplement,
known sensitivity to resveratrol, curcumin, green tea, or quercetin

Where it is running

Public Health Research Center — Columbia, South Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.