Pleural Manometry for the Characterization of Spontaneous and Tension Pneumothorax

Completed

Conditions studied: Pneumothorax, Tension Pneumothorax

In brief

Intrapleural pressures have been shown to be a useful clinical predictor in pleural effusions, however it's utility has not been described in pneumothorax. Data on intrapleural pressures in pneumothorax are limited. Furthermore, the pleural pressure in tension pneumothorax is theorized to be greater than atmospheric pressure, though this has never been verified. Pneumothorax is primarily treated with a tube thoracostomy. This observational study will record intrapleural pressures in participants with pneumothorax undergoing a tube thoracostomy. Clinical outcomes of participants will then be monitored for need for pleurodesis, intrabronchial valve placement, and video assisted thoracoscopic surgery (VATS) to identify a correlation with intrapleural pressure.

Key facts

Study ID: NCT04630301
Run by: Johns Hopkins University
People needed: 37
Starts: 2021-02-17
Expected to finish: 2025-07-31
Last updated by the study team: 2025-10-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

patients aged 18 or older admitted to the Johns Hopkins Hospital with clinical or radiographic evidence of new pneumothorax who are referred to Interventional Pulmonology for needle aspiration or tube thoracostomy. TP will be defined as a pneumothorax that results in mean arterial pressure <65 or systolic BP < 90.

You may not qualify if…

bilateral pneumothorax

Where it is running

Johns Hopkins Hospital — Baltimore, Maryland, United States
University of Michigan Medical School — Ann Arbor, Michigan, United States
Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
Albany Medical Center — Albany, New York, United States

Full record on ClinicalTrials.gov

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