Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
Recruiting now
Conditions studied: Acute Febrile Illness
In brief
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in Laos, Myanmar, Thailand, the Thai-Myanmar border region, and Bangladesh and presenting with acute febrile illnesses (≤ 14 days duration) to participating health facilities. This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z
Key facts
- Study ID
- NCT04629053
- Run by
- University of Oxford
- People needed
- 7200
- Starts
- 2022-06-21
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-01-12
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
- Aged > 28 days (day of birth = Day 1);
- Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR < 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
- Onset of illness ≤ 14 days
You may not qualify if…
- Accident or trauma is the cause for the patient's presentation;
- Presentation ≤ 3 days after routine immunisations
- Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
- The treating healthcare worker's decision is to send the patient home following initial assessment.
Where it is running
- Laos-Oxford-Mahosot Wellcome Trust Research Unit — Vientiane, Laos (enrolling)
- Shoklo Malaria Research Unit — Mae Sot, Changwat Tak, Thailand (enrolling)
- Chiangrai Clinical Research Unit (CCRU) — Chiang Rai, Thailand (enrolling)
- Building Resources Across Communities (BRAC) — Dhaka, Bangladesh
Full record on ClinicalTrials.gov
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