A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Advanced Solid Tumors
In brief
This study is researching an investigational drug called marlotamig (REGN7075) by itself and in combination with cemiplimab with or without chemotherapy. The study is focused on patients with certain solid tumors that are in an advanced stage. The aim of the study is to see how safe and tolerable marlotamig is by itself and in combination with cemiplimab (with or without chemotherapy), and to find out what is the best dose of marlotamig to be given to patients with advanced solid tumors when combined with cemiplimab (with or without chemotherapy). Another aim of the study is to see how effective marlotamig by itself, or in combination with cemiplimab (with or without chemotherapy), is at treating cancer patients. The study is also looking at: * Side effects that may be experienced by people taking marlotamig by itself and in combination with cemiplimab with or without chemotherapy * How marlotamig works in the body by itself and in combination with cemiplimab with or without chemotherapy * How much marlotamig is present in the blood when given by itself and in combination with cemiplimab with or without chemotherapy * To see if marlotamig by itself and in combination with cemiplimab with or without chemotherapy works to treat cancer by controlling the proliferation of tumor cells to shrink the tumor * Whether the body makes antibodies against the study drugs (marlotamig and cemiplimab) (which could make the drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT04626635
- Run by
- Regeneron Pharmaceuticals
- People needed
- 548
- Starts
- 2020-12-21
- Expected to finish
- 2027-03-05
- Last updated by the study team
- 2026-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California Los Angeles (UCLA) Medical Center — Los Angeles, California, United States
- The Regents of the University of California, San Francisco — San Francisco, California, United States
- University of Colorado Hospital - Anschutz Cancer Pavilion - Lung Cancer Clinic — Aurora, Colorado, United States
- University of Florida Health — Gainesville, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- University of Illinois Cancer Center — Chicago, Illinois, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- START Midwest - Cancer & Hematology Centers of Western Michigan, PC — Grand Rapids, Michigan, United States
- Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- University of Cincinnati Medical Center — Cincinnati, Ohio, United States
- The Stefanie Spielman Comprehensive Breast Center — Columbus, Ohio, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Sarah Cannon Research Institute - 25th Ave — Nashville, Tennessee, United States
- Vanderbilt Ingram Cancer Center — Nashville, Tennessee, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- South Texas Oncology And Hematology — San Antonio, Texas, United States
- University of Washington/Fred Hutchinson Cancer Center — Seattle, Washington, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Centre Leon Berard (CLB) - Centre de Recherche en Cancerologie Lyon-Est (CRCL) — Lyon, Auvergne-Rhone, France
- Hopital Lyon Sud — Pierre-Bénite, Auvergne-Rhône, France
- Centre Georges Francois Leclerc — Dijon, Bourgogne-Franche-Comté, France
- Institut Claudius Regaud, IUCT-Oncopole — Toulouse, Haute-Garonne, France
- Centre Hospitalier Universitaire (CHU) de Lille — Lille, Hauts-de-France, France
- Valkyrie Clinical Trials — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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