COMT Activity and Hypnotizability

Completed

Conditions studied: Pain, Postoperative, Genetic Predisposition

In brief

Hypnosis is an effective pain management tool for surgery that can reduce opioid use up to 40%. COMT single nucleotide polymorphisms (SNPs) can predict pain sensitivity and opioid use perioperatively, and may also be associated with hypnotizability or response to hypnotic analgesia. Analyzing COMT haplotypes from DNA extracted from saliva or blood using a giant magnetoresistive (GMR) nanotechnology platform may be faster, less expensive, and at least as accurate as pyrosequencing. This study aims to validate a multi-SNP point-of-care (POC) GMR assay for the rapid genotyping of SNPs predictive of COMT activity, and test the feasibility of using COMT activity as a biomarker for hypnotizability and/or response to hypnotic analgesia.

Key facts

Study ID

NCT04624880

Run by

Stanford University

People needed

80

Starts

2021-01-13

Expected to finish

2021-07-13

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Prior enrollment in one of 3 specific hypnosis trials
• Enrollment is by invitation only

You may not qualify if…

• Participants in the prior trials who declined to be contacted for future research.

Where it is running

• Stanford University/Stanford Healthcare — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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