A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
Running, not enrolling · Phase 3 · Has a placebo group
Conditions studied: Sickle Cell Disease
In brief
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain).
Key facts
- Study ID
- NCT04624659
- Run by
- Forma Therapeutics, Inc.
- People needed
- 450
- Starts
- 2021-01-29
- Expected to finish
- 2027-03-19
- Last updated by the study team
- 2026-04-06
Who can join
Age: 12 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hsptl — Phoenix, Arizona, United States
- [Legal] Woodland International Research Group, LLC — Little Rock, Arkansas, United States
- [Legal] Collaborative Neuroscience Network, LLC — Long Beach, California, United States
- Pacific Research Partners — Oakland, California, United States
- UCSF Oakland Benioff ChildHosp — Oakland, California, United States
- University Of California Irvine — Orange, California, United States
- UC Davis Medical Center — Sacramento, California, United States
- University of Connecticut — Farmington, Connecticut, United States
- Yale University — New Haven, Connecticut, United States
- Children's National Health Hospital — Washington D.C., District of Columbia, United States
- Howard University — Washington D.C., District of Columbia, United States
- Cornerstone Research Institute — Altamonte Springs, Florida, United States
- University of Florida — Gainesville, Florida, United States
- Foundation for Sickle Cell Disease Research — Hollywood, Florida, United States
- University Of Miami — Miami, Florida, United States
- Advanced Pharma CR — Miami, Florida, United States
- Arnold Palmer Children's Hospital — Orlando, Florida, United States
- Emory University School of Medicine — Atlanta, Georgia, United States
- Sonar Clinical Research — Atlanta, Georgia, United States
- Children's Healthcare of Atlanta Investigational Medication Pharmacy — Atlanta, Georgia, United States
- Center for Blood Disorders Augusta University — Augusta, Georgia, United States
- iResearch Atlanta, LLC — Decatur, Georgia, United States
- University of Illinois at Chicago — Chicago, Illinois, United States
- Children's Hosp-New Orleans — New Orleans, Louisiana, United States
- Univ of Alabama Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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