Genetic Investigation of Cancer Predisposition
Starting soon
Conditions studied: Genetic Predisposition, Cancer
In brief
Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.
Key facts
- Study ID
- NCT04620278
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 100
- Starts
- 2026-10-01
- Expected to finish
- 2035-12-01
- Last updated by the study team
- 2026-01-06
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Any age
- Meets at least ONE of the following:
- Personal history (with documented diagnosis) of cancer before the age of 50
- Personal history of more than one primary cancer
- Documented diagnosis of cancer AND family history of that same cancer type or multiple other cancers that do not fit classical criteria of hereditary cancer syndromes
- Documented diagnosis of a rare cancer AND family history of rare cancers that do not fit classical criteria of hereditary cancer syndromes
- There is the same type of cancer in several generations of a family
- Documented diagnosis of multicentric cancers (e.g bilateral cancers in paired organs, or multifocal cancers in single organs) that usually occur as single lesions when presented sporadically
- Early onset cancer (before the age of 50, or breast cancer before age 45) AND family history of early onset cancer Capable of providing access to detailed medical records and family history of cancer
You may not qualify if…
- Established genetic diagnosis of a known hereditary cancer syndrome that is compatible with the clinical presentation
- Incarcerated
Where it is running
- University of Texas Health Science Center — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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