A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
Completed · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Non-small Cell Lung Cancer (NSCLC)
In brief
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase: * Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin * Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B).
Key facts
- Study ID
- NCT04619797
- Run by
- Hoffmann-La Roche
- People needed
- 542
- Starts
- 2020-12-15
- Expected to finish
- 2025-11-20
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- PIH Health Whittier Hospital — Whittier, California, United States
- SCRI Florida Cancer Specialists South — Fort Myers, Florida, United States
- SCRI Florida Cancer Specialists North — St. Petersburg, Florida, United States
- Advent Health Orlando — Winter Park, Florida, United States
- Northwest Georgia Oncology Centers PC - Marietta — Marietta, Georgia, United States
- Fort Wayne Medical Oncology and Hematology, Inc — Fort Wayne, Indiana, United States
- Baptist Health Lexington — Lexington, Kentucky, United States
- Tennessee Oncology Chattanooga — Chattanooga, Tennessee, United States
- Sarah Cannon Research Institute / Tennessee Oncology — Nashville, Tennessee, United States
- Inova Schar Cancer Institute — Fairfax, Virginia, United States
- AZORG Campus Aalst-Moorselbaan — Aalst, Belgium
- Cliniques Universitaires St-Luc — Brussels, Belgium
- CHU UCL Mont-Godinne — Mont-godinne, Belgium
- Vitaz — Sint-Niklaas, Belgium
- Crio - Centro Regional Integrado de Oncologia — Fortaleza, Ceará, Brazil
- Oncocentro Belo Horizonte — Belo Horizonte, Minas Gerais, Brazil
- Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda — Ijuí, Rio Grande do Sul, Brazil
- Hospital das Clinicas - UFRGS — Porto Alegre, Rio Grande do Sul, Brazil
- Hospital Nossa Senhora da Conceicao — Porto Alegre, Rio Grande do Sul, Brazil
- Hospital de Cancer de Barretos — Barretos, São Paulo, Brazil
- Instituto do Cancer do Estado de Sao Paulo - ICESP — São Paulo, São Paulo, Brazil
- Cross Cancer Institute — Edmonton, Alberta, Canada
- Royal Victoria Regional Health Centre — Barrie, Ontario, Canada
- Lakeridge Health Oshawa — Oshawa, Ontario, Canada
- UCLA — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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