Defining and Treating Depression-related Asthma
Completed · Early Phase 1
Conditions studied: Asthma, Depression, Childhood Asthma
In brief
Depression is seen more often in people with asthma, and may lead to increased development and severity of asthma. This study will investigate whether children with depression and asthma have less allergic disease and less inflammation than children with asthma who do not have symptoms of depression. The study will also investigate whether the lungs of children with depression and asthma respond to an anticholinergic inhaler called ipratropium more than the lungs of non-depressed asthmatic children.
Key facts
- Study ID
- NCT04617015
- Run by
- State University of New York at Buffalo
- People needed
- 39
- Starts
- 2016-09-09
- Expected to finish
- 2019-03-11
- Last updated by the study team
- 2026-04-23
Who can join
Age: 7 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of asthma
- Decreased lung volumes for age/height/race (FEV1 <80% predicted or ratio of FEV1 to forced vital capacity (FVC) < 85%) on day of study visit assessed by spirometry.
You may not qualify if…
- Severely developmentally delayed patients, or those who suffer from other severe cognitive impairment not allowing them to perform spirometry or participate in study instruments.
- Patients who are pregnant or nursing.
- Patients with significant cardiopulmonary disease other than asthma, including cystic fibrosis, alpha-1-antitrypsin deficiency, interstitial lung disease, tracheo-/bronchomalacia, or cyanotic congenital cardiac defect.
- Patients with glaucoma, myasthenia gravis, or bladder neck obstruction (anticholinergics can worsen these conditions).
- Patients currently taking another anticholinergic medication
Where it is running
- Women and Children's Hospital of Buffalo — Buffalo, New York, United States
Full record on ClinicalTrials.gov
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