Medication Adherence Given Individual SystemCHANGE(TM) in Advancing Nephropathy (MAGICIAN) Pilot Study

Completed · Not applicable

Conditions studied: Chronic Kidney Disease(CKD)

In brief

The purpose of this 2-group, randomized, controlled trial is to evaluate the refined SystemCHANGE™ against attention control patient education in CKD patients taking RAAS medications.

Key facts

Study ID

NCT04616612

Run by

Indiana University

People needed

150

Starts

2021-12-15

Expected to finish

2024-02-06

Last updated by the study team

2025-04-23

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age > 18 years
• prescribed at least 1 daily RAAS inhibiting medication
• CKD diagnosis estimated glomerular filtration rate (eGFR) category G1 to G4
• RAAS inhibiting medication adherence of <.85 documented during the screening phase
• proteinuria defined as a urine Protein-to-Creatinine ratio > 150 mg/g or urine Albumin-to-Creatinine ratio >30mg/g
• able to speak, hear, and understand English determined by the ability to participate and comprehend conversation about potential inclusion in the study
• self-reported ability to open a pill cap
• able to self-administer RAAS inhibiting medications
• willing to use a study phone
• has no cognitive impairment as determined by a score of 4 or greater on the 6-item Telephone Mental Status Screen Derived from the Mini-Mental Status Exam (cognitive screener)
• has no other diagnoses that may shorten life span, such as metastatic cancer
• is not currently hospitalized
• receives care through two approved health care systems

You may not qualify if…

• Participants with kidney failure defined by GFR <15 mL/min/1.73
• Participants will be excluded if they are receiving dialysis or have dialysis access placed (e.g. graft or arteriovenous fistula) in anticipation of starting dialysis.
• Kidney and kidney-pancreas transplant recipients will be excluded.

Where it is running

• Indiana University School of Nursing — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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