Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

Recruiting now

Conditions studied: E Cigarette Use

In brief

This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Key facts

Study ID

NCT04616313

Run by

Western University, Canada

People needed

150

Starts

2023-01-17

Expected to finish

2027-12-01

Last updated by the study team

2025-08-14

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
• Male and female participant age ≥16 years.
• Participant has recently started vaping, >1 and <5 years weekly use.
• 70 participants will be c-cigarette never users.
• 70 participants will be former or current c-cigarette users.
• 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.

You may not qualify if…

• Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
• Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
• Participant unable to perform spirometry or plethysmography maneuvers.

Where it is running

• Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre — London, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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