Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery

Recruiting now

Conditions studied: Breast Cancer

In brief

This study will primarily identify longitudinal associations between cardiorespiratory fitness (CRF) and cognitive function pre- (baseline) to post-chemotherapy (\~3 months). This will be a prospective study of 50 BCS. We hypothesize that breast cancer patients undergoing chemotherapy who have higher levels of CRF at baseline will have significantly improved measures of attention, executive function, and memory post-chemotherapy. In addition, the exploratory aims will examine the longitudinal associations between physical activity (PA) and cognitive function from pre- to post-chemotherapy and explore the associations between inflammatory and non-inflammatory biomarkers and CRF with cognitive function.

Key facts

Study ID

NCT04616300

Run by

University of Toronto

People needed

50

Starts

2019-12-12

Expected to finish

2025-04-30

Last updated by the study team

2024-12-06

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 18-65 years old
• histologically-confirmed stage I-III breast cancer, but prior to the initiation of chemotherapy (<1 cycle of adjuvant therapy or neoadjuvant therapy)
• no diagnosed major cognitive disorders and uncontrolled comorbidities.

You may not qualify if…

• received neoadjuvant chemotherapy and scheduled to receive adjuvant chemotherapy
• scheduled to receive concurrent radiation therapy with chemotherapy.

Where it is running

• Sunnybrook Health Sciences Centre-Odette Cancer Centre — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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