Symptom Screening Linked to Care Pathways

Completed · Not applicable

Conditions studied: Pediatric Cancer, Quality of Life

In brief

Most children with cancer survive because they are given intensive treatments, but unfortunately, these treatments are associated with distressing symptoms. To address this problem, we developed the Symptom Screening in Pediatrics Tool (SSPedi) so that children receiving cancer treatments can communicate their bothersome symptoms, and Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK), a web-based application that links identified symptoms to supportive care guidelines for symptom management. To establish that these tools improve the lives of children newly diagnosed with cancer, we will conduct a trial that randomizes 20 pediatric cancer institutions and measures the impact of three times weekly symptom screening, symptom feedback to healthcare providers and the development of care pathways for symptom management to improve total symptom burden, fatigue and quality of life.

Key facts

Study ID

NCT04614662

Run by

The Hospital for Sick Children

People needed

445

Starts

2021-08-02

Expected to finish

2023-10-25

Last updated by the study team

2025-09-23

Who can join

Age: 8 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 8-18 years of age at enrollment
• English or Spanish-speaking
• Any newly diagnosed cancer
• Have a plan for any chemotherapy, radiotherapy or surgery
• Enroll within 28 days after treatment initiation

You may not qualify if…

• Cognitive disability (attending minimum second grade or equivalent)
• Visual impairment (cannot see SPARK even with corrective lens)

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• The Leland Stanford Junior University — Redwood City, California, United States
• University of Colorado Denver — Aurora, Colorado, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• Nemours Children's Hospital, Delaware — Wilmington, Delaware, United States
• Nemours Children's Health, Jacksonville — Jacksonville, Florida, United States
• Nemours Children's Hospital, Florida — Orlando, Florida, United States
• Kapi'olani Medical Center for Women & Children — Honolulu, Hawaii, United States
• Unity Point Health - Blank Children's Hospital — Des Moines, Iowa, United States
• The University of Iowa — Iowa City, Iowa, United States
• Children's Hospital — New Orleans, Louisiana, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Roswell Park Comprehensive Cancer Center — Buffalo, New York, United States
• The Trustees of Columbia University in the City of New York — New York, New York, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Driscoll Children's Hospital — Corpus Christi, Texas, United States
• The University of Texas M. D. Anderson Cancer Center — Houston, Texas, United States
• The University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
• Virginia Commonwealth University — Richmond, Virginia, United States
• The Hospital for Sick Children — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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