Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Sickle Cell Disease, Sickle Cell Crisis, Pain, Acute

In brief

Sickle cell crisis continues to be a frequent presentation to emergency departments. Patients presenting will often require immediate treatment for their pain and often times this will include opioids. The opioid epidemic has cost thousands of lives; and continues to be a significant problem posing several challenges when treating patients presenting with sickle cell disease. Primarily, opioids remain the mainstay of treatment for these patients and the push to address the opioid crisis may present challenges for adequate opioid administration in patients suffering from a sickle cell crisis while hospitals find ways to curb the opioid crisis overall. Opioid treatment for patients in acute vaso-occlusive crisis has significantly contributed to quality of life and life expectancy of patients with this diagnosis. Measures should continue to attempt to administer a multi-model approach to sickle cell patients to minimize the morphine milligram equivalents in these patients while also successfully addressing the patient's pain. IV lidocaine is a pain medication that has been evaluated in several painful experiences, such as in renal colic. A few case reports have shown IV lidocaine use in sickle cell can be a potential effective adjunct medication to opioids to treat pain and reduce further opioid requirements. Currently, no prospective controlled trial exists to evaluate the true benefit of IV lidocaine in this population. Our study aims to evaluate IV lidocaine as an adjunct to opioid treatment in the emergency department to determine if improved pain is achieved and if there is a reduction in overall morphine milligram equivalents throughout the emergency department visit.

Key facts

Study ID

NCT04614610

Run by

Community Medical Center, Toms River, NJ

People needed

100

Starts

2024-01-01

Expected to finish

2025-06-01

Last updated by the study team

2023-08-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients > 18 years old with sickle cell disease experiencing persistent severe (7-10/10) pain despite receiving at least one dose of intravenous opiate analgesic.

You may not qualify if…

• Patients < 18 years old and pregnant
• Patients presenting with or suspected to have acute chest syndrome
• Allergy or intolerance to lidocaine products or morphine/hydromorphone

Where it is running

• Monmouth Medical Center — Long Branch, New Jersey, United States
• Robert Wood Johnson University Hospital — New Brunswick, New Jersey, United States
• Newark Beth Israel Medical Center — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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