MICRO: a Registry Study in Patients With Microvascular Angina
Recruiting now
Conditions studied: Microvascular Disease
In brief
The evidence above demonstrates that microvascular dysfunction is an important determinant of patient prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear definition for this disease has a potentially large clinical importance. It is important to better describe the phenotype of these patients, identify the predictors of prognosis, and determine the impact of diagnosis.
Key facts
- Study ID
- NCT04612322
- Run by
- Johannes Gutenberg University Mainz
- People needed
- 1000
- Starts
- 2020-10-10
- Expected to finish
- 2029-10-10
- Last updated by the study team
- 2022-03-31
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 and <85 years.
- Chronic coronary syndrome (including patients with anginal equivalents)
- Angina CCS class II-IV
- Evidence of reversible ischemia on non-invasive testing
- Availability of the following measurements:
- Index of microvascular resistances (IMR),
- Resting full-cycle ratio (RFR),
- Fractional flow reserve (FFR),
- Coronary flow reserve (CFR)
- Willingness to participate and ability to understand read and signed the informed consent document before the procedure
You may not qualify if…
- At least one of the following:
- Pregnancy and or lactation.
- Medical or psychological conditions that would jeopardize an adequate and orderly participation.
- Left ventricular ejection fraction lower than 30%
- Previous coronary artery bypass surgery (CABG) to all major branches in the LAD and left circumflex (LCX) territory, such that IMR cannot be measured
- Decompensated congestive heart failure (CHF)
- Chronic or acute renal failure with creatinine >2mg/dl
- Severe valvular heart disease
- Patients with comorbidities limiting life expectancy to less than one year
Where it is running
- Universitätsmedizin Mainz — Mainz, RLP, Germany (enrolling)
Full record on ClinicalTrials.gov
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