Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH
Completed
Conditions studied: Scleroderma, Pulmonary Artery Hypertension
In brief
This observational study is being done to understand why people with scleroderma can develop pulmonary arterial hypertension (high blood pressure in the lungs, abbreviated PAH) and a weak heart muscle (heart failure). The study will also help the investigators understand why people with PAH from an unknown cause (called idiopathic PAH, or IPAH) can also develop a weakened heart muscle. The response of the right side of the heart or right ventricle (RV) to standard PAH therapy in scleroderma-associated PAH and in IPAH will be assessed. Blood and tissue samples will be collected from research participants during participants' normal standard of care procedures. People with scleroderma-associated PAH or idiopathic cause (IPAH) who need a right heart catheterization may join this study.
Key facts
- Study ID
- NCT04610788
- Run by
- Johns Hopkins University
- People needed
- 43
- Starts
- 2019-04-15
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2026-01-09
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients 18 years or older with clinically diagnosed scleroderma or presumed/known idiopathic pulmonary hypertension.
You may not qualify if…
- Patients found to have secondary pulmonary hypertension (PH due to left heart failure) on clinical RHC.
- Hemodynamically unstable patients (systolic blood pressure < 90mmHg, vasopressor requirement).
- Patients whom are unable to give consent for themselves.
- Patients with RV clot or septal aneurysm will be excluded.
- In order to undergo the clinical right heart catheterization procedures, pregnancy testing (urine or serum) is standard of care.
- Pregnancy
Where it is running
- Johns Hopkins — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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