Connect for Cancer Prevention Study (Connect)

Recruiting now

Conditions studied: Cancer, General Research Use

In brief

Background: The National Cancer Institute, part of the National Institutes of Health, has partnered with nine health care systems across the U.S. to establish the Connect for Cancer Prevention Study. While researchers have made important discoveries, there is more to learn to lower the number of people affected by cancer. By taking part in Connect, participants can help researchers learn how the way we live, our genetics, and our health history may affect cancer risk. Objective: To study and better understand the causes of cancer and to find new ways to prevent it. Eligibility: The study will include 200,000 adults who get their health care from a partner health care system, are between 30 and 70 years old at enrollment, and have never had cancer. People remain eligible to join if they have or once had non-melanoma skin cancer, or a condition that may raise cancer risk (such as ductal carcinoma in situ, or DCIS). Design: Eligible recruits can sign up for Connect online by creating an account on MyConnect using their email address or phone number. After creating an account, they will complete the informed consent process. All information shared through MyConnect is secure to protect participant privacy. After joining the study, participants will be asked to answer online health surveys a few times a year, donate samples of blood, urine, and saliva every two to three years, and safely share access to their electronic health records with Connect. In the future, participants may donate unused samples that are collected at clinical visits, like tissue, stool, or blood, and may mail in samples collected at home. Participants may also share information from personal health trackers, like wearable devices or apps. This information will help researchers study the health and behavior patterns that may affect cancer risk. It takes time to understand the causes of cancer, so Connect will go on for many years. The longer people participate, the more researchers may learn. Participants can leave the study at any time. Learn more about Connect by visiting cancer.gov/connectstudy.

Key facts

Study ID

NCT04609072

Run by

National Cancer Institute (NCI)

People needed

200000

Starts

2021-07-26

Expected to finish

2070-12-31

Last updated by the study team

2026-07-08

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• An individual who meets any of the following criteria at time of initial study invitation will be excluded from participation in this study:
• Individuals with a confirmed history of invasive cancer (other than non-melanoma skin cancer)
• Individuals with known cognitive impairment documented in their medical record

Where it is running

• Marshfield Clinic Health System — Marshfield, Wisconsin, United States (enrolling)
• Kaiser Permanente Georgia — Atlanta, Georgia, United States (enrolling)
• Kaiser Permanente Hawaii — Honolulu, Hawaii, United States (enrolling)
• Kaiser Permanente Colorado — Denver, Colorado, United States (enrolling)
• Henry Ford Health Systems — Detroit, Michigan, United States (enrolling)
• HealthPartners — Minneapolis, Minnesota, United States (enrolling)
• Kaiser Permanente Northwest — Portland, Oregon, United States (enrolling)
• Sanford Health — Sioux Falls, South Dakota, United States (enrolling)
• Baylor Scott and White Health — Dallas, Texas, United States (enrolling)
• University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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