Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock
Completed · Early Phase 1 · Has a placebo group
Conditions studied: Aging, Epigenetics, Inflammatory Mediators
In brief
Topical Rapamycin ointment will be applied to participant forearms to test whether epigenetic changes in the skin are elicited.
Key facts
- Study ID
- NCT04608448
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 22
- Starts
- 2021-04-28
- Expected to finish
- 2022-04-15
- Last updated by the study team
- 2023-07-19
Who can join
Age: 65 and older, up to 95. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 65-95 years of age.
- Good health with all chronic diseases (hypertension, coronary artery disease, etc.) clinically stable.
- Selected subjects will be in good health (Per the World Health Organization, good health will be defined as complete physical, mental, and social well-being and not merely the absence of disease or infirmity).
- All diseases or infirmities will be clinically stable whether managed by medications or not.
- CLOX score of 10 or greater
- Women will be postmenopausal
- Postmenopausal women taking hormone replacement will be included if they have been on a stable dose for ≥6 months
- Live within a 20 mile drive of the UTHSA campus (7703 Floyd Curl Drive, San Antonio, TX)
You may not qualify if…
- Diabetes.
- History of skin ulcers or poor wound healing, or keloid formers.
- Smoking.
- Liver disease.
- Coumadin anti-coagulation.
- Treatment with drugs known to affect cytochrome P450 3A (diltiazem, erythromycin, etc. - due to role in rapamycin metabolism).
- Treatment with an immunosuppressant (prednisone, etc.) within 6 months.
- History of recent (within 6 months) Myocardial Infarction or active Coronary Disease.
- Hypersensitivity to rapamycin or petrolatum (ointment vehicle)
- Arm tattoos or scars in application area
Where it is running
- UTHSCSA — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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