Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC):

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Colorectal Cancer Metastatic, Myelosuppression-Adult, Chemotherapeutic Toxicity

In brief

This was a randomized, double-blind, placebo-controlled, global, multicenter, Phase 3 trial evaluating the impact of trilaciclib on myelopreservation and anti-tumor efficacy when administered prior to FOLFOXIRI/bevacizumab in patients with pMMR/MSS mCRC who have not received systemic therapy for metastatic disease.

Key facts

Study ID

NCT04607668

Run by

G1 Therapeutics, Inc.

People needed

326

Starts

2021-01-06

Expected to finish

2023-03-31

Last updated by the study team

2024-11-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years of age at the time of signing the informed consent. Patients > 70 years of age must have a G8 Health State Screening Tool (geriatric screening tool) score > 14.
• Proficient mismatch repair/microsatellite stable (pMMR/MSS), histologically or cytologically-confirmed adenocarcinoma of the colon or rectum. Patients with any BRAF or KRAS mutation status (wild type or mutant) are eligible. If historical pMMR/MSS and/or BRAF V600E mutational status are not known, a tumor specimen (archival or fresh biopsy) must be sent for testing and results must be available at the time of randomization in interactive web response system (IWRS). If testing cannot be completed using a standard clinical assay performed institutionally/locally, the tumor specimen may be sent to the Sponsor's designated central laboratory for analysis; only historical KRAS mutational status will be collected (ie, no testing required prior to study entry). Note: Any sample sent for MSS/BRAF analysis will be in addition to that required per Inclusion Criterion 5.
• Unresectable and measurable or metastatic colorectal cancer per RECIST v1.1
• ECOG performance status of 0 to 1
• A formalin-fixed paraffin-embedded (FFPE) tumor specimen (from archival or fresh biopsy) with an associated pathology report documenting pMMR/MSS mCRC must be confirmed to be available to send to the Sponsor for planned retrospective biomarker analyses (tissue requirements are provided in the associated laboratory manual).
• Hemoglobin ≥ 9.0 g/dL in the absence of RBC transfusion or ESA administration within 14 days prior to first dose of trilaciclib/placebo
• Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9 /L
• Platelet count ≥ 100 × 10\^9 /L
• Estimated glomerular filtration rate (eGFR) ≥ 30 mL/minute/1.73m\^2
• Total bilirubin ≤ 1.5 × upper limit of normal (ULN)
• AST, ALT, and alkaline phosphatase ≤ 3 × ULN for patients without liver or bone metastases; AST, ALT and alkaline phosphatase ≤ 5 × ULN in the presence of liver metastases; AST and ALT ≤ 3 x ULN and alkaline phosphatase ≤ 5 × ULN in the presence of bone metastases
• Resolution of nonhematologic toxicities from prior therapy or surgical procedures to ≤ Grade 1 or baseline (except alopecia)
• Urine dipstick protein < 2+. If ≥ 2+ at Screening, then a 24-hour urine collection must be done to demonstrate ≤ 1 g of protein/24 hours
• Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. Please see Section 17.4 for detailed instructions on methods of contraception requirements.
• Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

You may not qualify if…

• Prior systemic therapy for mCRC. Patients who received adjuvant/neoadjuvant therapy (ie, treatment with curative intent) for colorectal cancer are eligible if it has been ≥ 6 months between the last dose of systemic chemotherapy and the date of informed consent.
• Any radiotherapy, chemotherapy, immunotherapy, biologic, investigational, or hormonal therapy for cancer treatment (except for adjuvant hormonal therapy for breast cancer or prostate cancer defined as M0 disease or PSA persistence/recurrence without metastatic disease) within 3 weeks prior to the first dose of trilaciclib/placebo.
• Receipt of any low-dose systemic chemotherapeutic agent (e.g., low-dose methotrexate for rheumatoid arthritis) administered for a nononcologic purpose within 3 weeks prior to the first dose of trilaciclib/placebo.
• Presence of central nervous system (CNS) metastases/leptomeningeal disease requiring immediate treatment with radiation therapy or steroids (i.e., patient must be off steroids administered for brain metastases for at least 14 days prior to the first dose of trilaciclib/placebo).
• QTcF interval > 450 msec (males) or > 470 msec (females) at screening. For patients with ventricular pacemakers, QTcF > 500 msec.
• Personal or family history of long QT syndrome
• Symptomatic peripheral neuropathy
• History of interstitial lung disease (ILD)
• Uncontrolled hypertension (blood pressure ≥ 150/90mm Hg)
• Clinically significant (i.e., active) cardiovascular disease at the time of signing the informed consent; for example cerebrovascular accidents (≤ 6 months before the first dose of trilaciclib/placebo), myocardial infarction (≤ 6 months before the first dose of trilaciclib/placebo), unstable angina, serious cardiac arrhythmia requiring medication, or uncontrolled symptomatic congestive heart failure [Class II or higher as defined by the New York Heart Association [NYHA] functional classification system])
• Serious, non-healing wound, ulcer, or bone fracture
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study treatment start, or anticipation of the need for major surgical procedure during the course of the study.
• Known serious active infection (e.g., human immunodeficiency virus [HIV], hepatitis B or C, tuberculosis, etc.)
• Known Gilbert's Syndrome or homozygous for the UGT1A1*28 allele. UGT1A1 genotyping is not required for this study.
• Chronic inflammatory bowel disease and/or active intestinal obstruction. Patients should not be treated until the intestinal obstruction has resolved.
• Previous history of significant/severe hemorrhage, within 1 month before randomization. History of previous abdominal fistula or gastrointestinal perforation within 6 months before randomization
• Known history of bleeding diathesis or coagulopathy
• INR > 1.5 within 14 days prior to starting study treatment. EXEMPTION: patients on full anticoagulation must have an in-range INR (usually between 2 to 3) if INR is used for monitoring. Any anticoagulation therapy must be at stable dosing prior to enrollment.
• Ongoing or anticipated treatment with potent cytochrome inhibitors CYP450 3A4 (such as ketoconazole) or inducers (such as rifampicin, carbamazepine, phenobarbital, phenytoin or St. John's wort). Irinotecan should not be delivered concurrently.
• Patients with ongoing or anticipated treatment with sorivudine or its chemically related analogues, such as brivudine.
• Chronic, daily treatment with high-dose aspirin (> 325 mg/day)
• Prior allogeneic or autologous hematopoietic stem cell or bone marrow transplantation
• Receipt of any live attenuated vaccines within 4 weeks prior to first dose of study treatment
• Known hypersensitivity to any of the drugs used in this study
• Pregnant or lactating women

Where it is running

• Beverly Hills Cancer Center — Beverly Hills, California, United States
• Keck Medical Center of USC Pasadena — Los Angeles, California, United States
• The Oncology Institute of Hope & Innovation\ Innovative Clinical Research Institute — Whittier, California, United States
• Georgetown University - Lombardi Comprehensive Cancer Center — Washington D.C., District of Columbia, United States
• Florida Cancer Specialists (South Region) — Fort Myers, Florida, United States
• Florida Cancer Specialists NORTH — Fort Myers, Florida, United States
• Mid-Florida Hematology & Oncology Centers, P.A. — Orange City, Florida, United States
• Florida Cancer Specialists — St. Petersburg, Florida, United States
• Florida Cancer Specialists - Panhandle — Tallahassee, Florida, United States
• Northside Hospital - Georgia Cancer Specialists — Atlanta, Georgia, United States
• Illinois Cancer Specialists — Arlington Heights, Illinois, United States
• Boston Medical Center — Boston, Massachusetts, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• Mayo Clinic - Rochester — Rochester, Minnesota, United States
• Comp. Cancer Centers of Nevada — Las Vegas, Nevada, United States
• University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Gettysburg Cancer Center — Gettysburg, Pennsylvania, United States
• Tennessee Oncology — Nashville, Tennessee, United States
• UT Southwestern Medical Center — Dallas, Texas, United States
• Millennium Oncology — Kingswood, Texas, United States
• Inova Schar Cancer Institute — Fairfax, Virginia, United States
• Onc and Hem Assoc of SW VA — Roanoke, Virginia, United States
• Henan Cancer Hospital — Zijingshan, Henan, China
• AZ Oncology Associates - HOPE — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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