Intervention to Reduce Early (Peanut) Allergy in Children

Completed · Not applicable

Conditions studied: Food Allergy Peanut, Food Allergy in Infants

In brief

iREACH is a five-year NIH funded study aimed at assessing and improving pediatric clinician adherence to the 2017 NIAID Prevention of Peanut Allergy (PPA) Guidelines. iREACH has been developed as an electronic health record (EHR) integrated Clinical Decision Support (CDS) tool together with educational modules on the PPA guidelines to assist clinicians in implementing the 2017 NIAID PPA Guidelines. A practice-based, two-arm, cluster-randomized clinical trial will evaluate the effectiveness of iREACH in increasing pediatric clinician adherence to the PPA Guidelines and explore the end-goal of reducing peanut allergy incidence by age 2.5 years in the intervention vs control group. This study has the potential to: 1) provide evidence regarding the effectiveness of iREACH in promoting clinical processes and outcomes related to the PPA Guidelines, 2) provide important insight about practice-based implementation of PPA Guidelines by pediatric clinicians, allergists and caregivers, and 3) facilitate rapid, widespread implementation of PPA Guidelines and reduce peanut allergy incidence across the US.

Key facts

Study ID

NCT04604431

Run by

Ann & Robert H Lurie Children's Hospital of Chicago

People needed

30

Starts

2020-11-04

Expected to finish

2024-07-26

Last updated by the study team

2026-04-08

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Practice sites
• The practice utilizes a centrally-integrated EHR.
• The practice has signed a legally-binding engagement agreement with Lurie Children's Pediatric Practice Research Group.
• The practice employs at least one physician who has completed a residency in general pediatrics and is practicing as a general pediatrician.
• Pediatric Clinicians:
• Clinician is a physician, physician assistant, resident, advanced practice nurse, family practitioner, or pediatric nurse practitioner working in a pediatric practice.
• Clinician is employed by a practice that is a member of one of the participating practices in the study.
• Clinician provides well child care to infants ages 4 or 6 months.
• Infants • Infant has been seen by a pediatric clinician in the intervention or control arm for a 4- and/or 6-month WCC.
• Caregivers
• Is the caregiver of an infant seen for a 4- and/or 6-month WCC by a pediatric clinician in a practice belonging to the study's intervention or control arms.
• Is 18+ years of age or has parent or guardian permission to participate.
• Is able to understand the study and provide informed consent for the 12- and 24-month (child's age) survey.

You may not qualify if…

• Practice Sites
• Sees <50 newborn patients/year.
• Has only temporary pediatricians on staff.
• The practice pediatric clinicians do not use an EHR system.
• Pediatric clinicians
• The clinician is a temporary employee.
• The clinician begins employment at participating practice less than three months prior to end of the 18-month study enrollment period.
• Infants
• The infant has a medical condition that chronically inhibits the ability to take food orally (i.e., dysphagia, muscular dystrophy, gastrostomy).
• The infant has past or current medical problems or findings from physical examination or laboratory testing not listed above for which the pediatric clinician indicates that implementation of PPA Guidelines may pose a medical risk other than allergic reactions or may interfere with the infant's appropriate implementation of the PPA Guidelines or study investigators conclude that implementation of the PPA Guidelines was not possible or may have impacted the quality or interpretation of the data obtained from the study.
• Caregivers
• Caregiver's primary language is not English or Spanish.

Where it is running

• Pediatric Associates of Arlington Heights, SC-PEDIATRUST — Arlington Heights, Illinois, United States
• OSF Medical Group Pediatrics Bloomington — Bloomington, Illinois, United States
• Child and Adolescent Health Associates — Chicago, Illinois, United States
• Northwestern Children's Practice — Chicago, Illinois, United States
• Streeterville Pediatrics — Chicago, Illinois, United States
• Erie Family Health Centers - Erie Teen and Young Adult Health Center — Chicago, Illinois, United States
• Erie Family Health Centers - West Town — Chicago, Illinois, United States
• Erie Family Health Centers - Helping Hands - Foster — Chicago, Illinois, United States
• Lurie Children's Primary Care Town & Country Pediatrics — Chicago, Illinois, United States
• Near North Health Services Corporation — Chicago, Illinois, United States
• Children's Health Associates — Chicago, Illinois, United States
• Lakeview Pediatrics — Chicago, Illinois, United States
• OSF Medical Group Pediatrics Danville — Danville, Illinois, United States
• Erie Family Health Centers - Evanston — Evanston, Illinois, United States
• Lurie Children's Primary Care Chicago Area Pediatrics — Evanston, Illinois, United States
• OSF Medical Group Pediatrics Godfrey — Godfrey, Illinois, United States
• Pediatric Partners, SC-PEDIATRUST — Highland Park, Illinois, United States
• Bedrose Pediatrics — Hoffman Estates, Illinois, United States
• Lake Shore Pediatrics, SC-PEDIATRUST — Libertyville, Illinois, United States
• OSF Medical Group (MG)-Morton Pediatrics — Morton, Illinois, United States
• Ad-Park Pediatrics, SC-PEDIATRUST — Northbrook, Illinois, United States
• Oak Park Pediatrics — Oak Park, Illinois, United States
• University of Illinois College of Medicine Peoria — Peoria, Illinois, United States
• OSF-Center for Health (CFH)-Route 91 — Peoria, Illinois, United States
• Woodfield Pediatrics, SC-PEDIATRUST — Schaumburg, Illinois, United States

Full record on ClinicalTrials.gov

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