Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma
Stopped early · Phase 1/Phase 2
Conditions studied: Gastric Adenocarcinoma
In brief
The purpose of this study was to evaluate the efficacy of derazantinib monotherapy or derazantinib in combination with paclitaxel and ramucirumab in patients with gastric adenocarcinoma (GAC) i.e. with human epidermal growth factor receptor 2 (HER2)-negative adenocarcinoma of the stomach or gastro-esophageal junction harboring fibroblast growth factor receptor 2 (FGFR2) genetic aberrations (GA).
Key facts
- Study ID
- NCT04604132
- Run by
- Basilea Pharmaceutica
- People needed
- 47
- Starts
- 2020-10-06
- Expected to finish
- 2022-11-21
- Last updated by the study team
- 2024-04-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Fundación Favaloro para la Docencia e Investigación Médica — Buenos Aires, Argentina
- Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo — Ciudad Autonoma Buenos Aires, Argentina
- Monash Medical Centre Clayton — Clayton, Australia
- Peter MacCallum Cancer Centre — Melbourne, Australia
- The Alfred Hospital — Prahran, Australia
- UZA — Edegem, Belgium
- UZ Leuven — Leuven, Belgium
- AZ Delta — Menen, Belgium
- Liga Norte-Rio-Grandense Contra o Câncer — Natal, Rio Grande do Norte, Brazil
- Fundação Doutor Amaral Carvalho — Jaú, Brazil
- Instituto Nacional de Câncer José Alencar Gomes da Silva — Rio de Janeiro, Brazil
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia — Santo André, Brazil
- Fundação Faculdade Regional de Medicina de São José do Rio Preto — São José do Rio Preto, Brazil
- CeCim Biocinetic — Santiago, Region Met, Chile
- Centro de Estudios Clínicos SAGA — Santiago, Chile
- Instituto Clinico Oncologico — Temuco, Chile
- Institut Sainte Catherine — Avignon, France
- CHU Besançon - Hôpital Jean Minjoz — Besançon, France
- Centre Georges François Leclerc — Dijon, France
- Hôpital Saint-Louis — Paris, France
- Hôpital Saint-Antoine — Paris, France
- Institut Gustave Roussy — Villejuif, France
- Universitaetsklinikum Ulm — Ulm, Baden-Wurttemberg, Germany
- AdventHealth Cancer Institute — Orlando, Florida, United States
Full record on ClinicalTrials.gov
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