Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer

Stopped early

Conditions studied: Gastric Cancer

In brief

This protocol is a single-institution feasibility study to identify the molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly Hispanic South Texas population. The study is broken down into two main parts: 1) To identify molecular differences in gastric adenocarcinoma (GAC) between Non-Hispanics and Hispanics, stratified by age, and in benign, pre-malignant, and malignant gastric lesions; and 2) To identify environmental and clinicopathological factors in Hispanics associated with specific molecular changes linked to the development of GAC.

Key facts

Study ID

NCT04600466

Run by

The University of Texas Health Science Center at San Antonio

People needed

129

Starts

2021-01-22

Expected to finish

2025-06-06

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 years or older
• Patient with histologically confirmed diagnosis of gastric adenocarcinoma
• Able to understand English or Spanish (only for the prospective cohort)
• GEJ adenocarcinoma Type II (within 1 cm above and 2 cm below the GEJ) and Type III (2-5 cm below the GEJ)
• Hyperplastic polyps

You may not qualify if…

• Clinically AND genetically confirmed diagnosis of well-established hereditary cancer syndrome
• Gastroesophageal junction (GEJ) adenocarcinoma Type I (1-5 cm above the GEJ) as they are treated as esophageal cancer
• Other benign or malignant histology types (i.e. leiomyoma, gastrointestinal stroma tumors, fundic gland polyps, etc.)

Where it is running

• Mays Cancer Center, UT Health San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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