Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

Recruiting now · Phase 2

Conditions studied: Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm

In brief

The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).

Key facts

Study ID

NCT04600089

Run by

Sam Tyagi

People needed

30

Starts

2020-12-08

Expected to finish

2027-08-01

Last updated by the study team

2025-10-20

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• willing to give informed consent
• scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair
• requires naloxone continuous infusion for spinal prophylaxis

You may not qualify if…

• allergy to ketamine, acetaminophen, or fentanyl
• diagnosis of schizophrenia
• history of hydrocephalus or central nervous system mass
• incarcerated individuals
• pregnant or lactating individuals

Where it is running

• University of Kentucky Medical Center — Lexington, Kentucky, United States (enrolling)

Full record on ClinicalTrials.gov

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