Corneal Biomechanical Analysis Using Brillouin Microscopy

Enrolling by invitation

Conditions studied: Keratoconus, Keratoconus, Unstable, Keratoconus, Stable

In brief

The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the cornea by evaluating the change in Brillouin metrics before and after treatments.

Key facts

Study ID

NCT04598932

Run by

The Cleveland Clinic

People needed

220

Starts

2021-06-01

Expected to finish

2026-12-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients aged 18-60 with keratoconus
• patients aged 18-60 with normal corneas,
• patients aged 18-60 undergoing refractive surgery (LASIK, PRK, SMILE)
• patients aged 18-60 with keratoconus undergoing CXL

You may not qualify if…

• outside age range
• history of previous ocular surgeries
• unable to cooperate for the Brillouin microscopic examination
• unable to provide informed consent

Where it is running

• Cleveland Clinic Cole Eye Institute — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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