COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE)
Running, not enrolling · Not applicable
Conditions studied: COVID-19
In brief
Background: People who are recovering from COVID-19 may continue to have problems that affect their daily life. For instance, they might feel overly tired. Researchers want to learn if exercise can help people recover after COVID-19 infection. Objective: To study if participation in a rehabilitation exercise program can help people recovering from COVID-19. Eligibility: Adults ages 18-80 with a lab-confirmed SARS-CoV2 infection (the virus that causes COVID-19), and are still having some symptoms. Design: Participants will have a medical history and physical exam. They will give blood and urine samples. They will have tests to measure heart and lung function. Their blood vessels will be assessed. Participants will have a computed tomography scan of the body. They will have an ultrasound of the muscles in their arms, legs, and chest. Participants will take a 6-minute walk test (6MWT). They will take other balance and movement tests. Participants will walk on a treadmill while hooked up to a monitor. Then they will be interviewed. It will be audio-recorded. Participants will complete surveys about their symptoms and daily activities. Participants will take a smell test. For this, they will identify different smells. They will also have memory, attention, and mental functioning tests. Participants will wear an activity monitor on their wrist 24 hours a day. They will exercise 3 times a week for 10 weeks by performing cardio-type exercise for 30 minutes. They will attend education classes once a week for 10 weeks. Participants will be contacted by phone or email every 3 months for 1 year after they complete the exercise part of the study. They will wear an activity monitor for up to 2 weeks.
Key facts
- Study ID
- NCT04595773
- Run by
- National Institutes of Health Clinical Center (CC)
- People needed
- 48
- Starts
- 2021-01-22
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-05-12
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Above normal performance (i.e., >=100% predicted) in the 6MWT based on normative data for gender and age
- History or cardiac condition as determined by NIH cardiology to be unsafe for exercise participation (e.g. ischemic heart disease, right- or left-sided heart failure, cor pulmonale or pulmonary hypertension, dilated or hypertrophic cardiomyopathy or non-idiopathic cardiomyopathy)
- Significant hepatic or renal dysfunction
- Cancer diagnosis with evidence of metastasis or a life expectancy of less than one year
- History of stroke resulting in impairments in functional mobility that limits safe participation
- Active substance abuse including ethyl alcohol (EtOH)
- Severe psychiatric disease, not responsive to treatment or medication
- History of diabetes and on insulin pump therapy, or uncontrolled diabetes with HbA1c > 9.0%
- Pregnancy
- Acceptance onto a lung transplant waiting list
- Extreme obesity with BMI > 40 kg/m2
- On medications that would influence exercise performance such as beta blockers or antiretroviral therapy
- Ongoing tobacco and/or nicotine product use
- Enrolled in another interventional clinical research trial
- Any other medical or health condition(s) that unduly increases the risk of exercise testing or training, affects the normal physiologic response to exercise testing or training, and/or would otherwise interfere with the ability to interpret the data as determined by the PI
Where it is running
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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