Excessive Supraventricular Activity and Atrial Fibrillation

Recruiting now

Conditions studied: Atrial Fibrillation, Atrial Flutter, Supraventricular Beat, Premature, Premature Supraventricular Beats, Premature Atrial Complex, Extrasystole, Atrial

In brief

The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.

Key facts

Study ID

NCT04593498

Run by

Karolinska Institutet

People needed

250

Starts

2022-11-01

Expected to finish

2028-02-15

Last updated by the study team

2024-03-06

Who can join

Age: 70 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with at least 30 supraventricular extra systole (SVES)/h or a supraventricular run of at least 20 beats on a Holter recording.

You may not qualify if…

• Age < 70 years, >89 years Atrial fibrillation / flutter Lifelong treatment with oral anticoagulant Patients with implantable cardiac device Congestive heart failure (CHF) with Ejection fraction (EF) ≤ 30% Severe valvular heart disease

Where it is running

• Danderyd Hospital — Stockholm, Sweden (enrolling)

Full record on ClinicalTrials.gov

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