ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries, Penetrating Injury, Blunt Injury, Major Trauma, Multiple Trauma
In brief
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in critically ill trauma patients. 2500 mechanically ventilated ICU patients admitted with a primary trauma diagnosis presenting to the ICU will be recruited into the study from participating study centres in Australia, New Zealand, Europe, and Saudi Arabia.
Key facts
- Study ID
- NCT04588311
- Run by
- Australian and New Zealand Intensive Care Research Centre
- People needed
- 2500
- Starts
- 2020-11-09
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2025-07-16
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- St. Gallen Cantonal Hospital — Sankt Gallen, Switzerland (enrolling)
- Auckland City Hospital — Grafton, Auckland, New Zealand (enrolling)
- Christchurch Hospital — Christchurch, Christchurch, New Zealand (enrolling)
- Middlemore Hospital — Auckland, Otahuhu, New Zealand (enrolling)
- Waikato Hospital — Hamilton, Waikato Region, New Zealand (enrolling)
- Wellington Hospital — Newtown, Wellington Region, New Zealand (enrolling)
- King Abdulaziz Medical City — Riyadh, Saudi Arabia (enrolling)
- University Medical Centre Ljubljana — Ljubljana, Slovenia (enrolling)
- University Medical Centre Maribor — Maribor, Slovenia (enrolling)
- University Hospital Bern — Bern, Switzerland (enrolling)
- Royal Prince Alfred Hospital — Camperdown, New South Wales, Australia (enrolling)
- St George Hospital — Kogarah, New South Wales, Australia (enrolling)
- Liverpool Hospital — Liverpool, New South Wales, Australia (enrolling)
- John Hunter Hospital — New Lambton Heights, New South Wales, Australia (enrolling)
- Royal North Shore Hospital — Saint Leonards, New South Wales, Australia (enrolling)
- Westmead Hospital — Westmead, New South Wales, Australia (enrolling)
- Royal Brisbane and Women's Hospital — Herston, Queensland, Australia (enrolling)
- Gold Coast University Hospital — Southport, Queensland, Australia (enrolling)
- Princess Alexandra Hospital — Woolloongabba, Queensland, Australia (enrolling)
- Royal Adelaide Hospital — Adelaide, South Australia, Australia (enrolling)
- The Alfred Hospital — Melbourne, Victoria, Australia (enrolling)
- Royal Melbourne Hospital — Melbourne, Victoria, Australia (enrolling)
- Royal Perth Hospital — Perth, Western Australia, Australia (enrolling)
- CHU-Charleroi Chimay — Charleroi, Belgium (enrolling)
- Helsinki University Hospital (HUS) — Helsinki, Finland (enrolling)
Full record on ClinicalTrials.gov
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