Comparison of Potassium Binders in the ER

Stopped early · Phase 4

Conditions studied: Acute Hyperkalemia, Oral Potassium Binders

In brief

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in hospital patients with acute hyperkalemia.

Key facts

Study ID

NCT04585542

Run by

University of California, Irvine

People needed

37

Starts

2020-10-20

Expected to finish

2025-01-31

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Plasma potassium > 5.5 mEq/L
• Age ≥18 years
• Patient able to provide written informed consent

You may not qualify if…

• Recent bowel surgery
• Ileus or bowel obstruction
• Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis
• Pregnancy
• Active psychiatric disorder
• Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option
• Dialysis session expected within 4 hours after randomization
• History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer
• Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)

Where it is running

• University of California, Irvine Medical Center — Orange, California, United States

Full record on ClinicalTrials.gov

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