A Study to Evaluate the Outcomes of Cannabinoid (CBD) Roll-on Topical Stick in Primary Total Knee Arthroplasty

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Pain, Joint, Pain, Postoperative, Total Knee Arthroplasty

In brief

Total knee arthroplasty (TKA) is one the most common surgical treatments performed for end stage degenerative arthritis of the knee. More than 700,000 procedures are currently performed yearly in the United States. This procedure usually results in moderate-to-severe pain in the immediate post-operative period. Optimal pain control may allow early mobilization, accelerate rehabilitation, improve patient satisfaction, decrease length-of-stay, and optimize functional outcomes. The challenge, however, is to manage pain with alternative methods, reducing the role of opiate medications, which are highly addictive with myriad side effects. In this prospective randomized double-blinded controlled study, the investigators aim to evaluate the benefits of an over-the-counter (OTC) transdermal CBD preparation in patients undergoing primary total knee arthroplasty as a novel adjunct to the standard multi-modal analgesic regimen, to reduce postoperative pain and reduce the need for opiates after total knee arthroplasty.

Key facts

Study ID

NCT04585230

Run by

Rothman Institute Orthopaedics

People needed

92

Starts

2020-10-12

Expected to finish

2021-05-28

Last updated by the study team

2020-10-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients who have general anesthesia
• Patients who have documented allergic reactions to ropivacaine in the local infiltration agents
• Patients who have a contra-indication to the use of non-steroidal anti-inflammatory medications or are using therapeutic anticoagulation precluding them from using non-steroidal anti-inflammatory medications
• Patients unable to complete a 100-ft walk baseline
• Patients undergoing total knee arthroplasty as a conversion procedure following previous surgery
• Patients undergoing TKA for posttraumatic arthritis
• Patients undergoing TKA for steroid-induced or spontaneous avascular necrosis
• Workers compensation patients
• Patients refusing or not candidates for peripheral nerve blocks
• Patients undergoing unicompartmental knee arthroplasty
• Patients undergoing patellofemoral arthroplasty
• Patients undergoing bilateral simultaneous or sequential primary total knee arthroplasty within the same hospital stay
• Patients who have previously reported allergy to tetrahydrocannabinol or other cannabinoid compounds or develop allergic reactions to the formulation following use
• Patients who are pregnant or choosing to be pregnant during the 6-week study period or are breast feeding during the study period
• Patients who are on chronic narcotics pre-operatively
• Patients who have end-stage cirrhosis, end-stage renal failures, or psychiatric conditions preventing adequate assessment of study outcome metrics
• Patients with adequate cognitive function to participate and complete questionnaires for the study.
• Patients unable or unwilling to follow-up and complete questionnaires for the study
• Patients with active cancer and undergoing treatment precluding the assessment of outcome metrics
• Patients with a history or diagnosis of chronic pain syndrome or Complex regional pain syndrome (CRPS)
• Patients who are determined to be in severe pain from other concomitant conditions

You may not qualify if…

• patients <18 and >80
• any patient who does not meet the inclusion criteria listed for this study

Where it is running

• Rothman Orthopaedic Institute — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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