A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
Starting soon · Not applicable
Conditions studied: Keratoconus
In brief
This randomized clinical trial will assess corneal astigmatism and visual outcomes in participants who have undergone corneal transplantation for keratoconus with ex vivo cross-linked donor corneal tissue versus participants who have undergone corneal transplantation for keratoconus with non-cross-linked donor corneas. Crosslinking is a procedure that stabilizes the biomechanical properties of the cornea; as a result, the cornea stiffens. It has been shown that this procedure stabilizes the cornea of patients with keratoconus or corneal ectasias. The FDA currently approves crosslinking for patients with progressive keratoconus and corneal ectasia following refractive surgery. Ex vivo crosslinking of donor corneal tissue for patients with keratoconus undergoing PK or DALK could stabilize the cornea and reduce the risk of high astigmatism and improve vision in patient with keratoconus.
Key facts
- Study ID
- NCT04584125
- Run by
- Joseph B. Ciolino, MD
- People needed
- 216
- Starts
- 2027-01-01
- Expected to finish
- 2028-11-30
- Last updated by the study team
- 2026-04-08
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Willing and able to provide written informed consent.
- Willing and able to comply with study assessments for the full duration of the study.
- Age ≥18 years but ≤50 years
- History of keratoconus (without a previous transplant) requiring keratoplasty
- Willing to commit to not having further cross-linking, corneal relaxing incisions, intacs, or corneal laser vision correction during the course of the study
You may not qualify if…
- Age < 18 years >50
- Inability to provide written informed consent and comply with study assessments for the full duration of the study
- Participation in another simultaneous interventional medical investigation or trial
- Systemic
- History of Stevens-Johnson syndrome or ocular pemphigoid
- Signs of current infection, including fever and current treatment with antibiotics
- Pregnancy (positive pregnancy test) or lactating
- Pre-menopausal sexually active women not using adequate contraception (Reliable intrauterine devices, hormonal contraception or a spermicide in combination with a barrier method)
- Recipient Eye
- Corneal or ocular surface infection within 30 days prior to study entry
- History of previous cross-linking
- History of previous corneal transplant
- Non-healing epithelial defect of at least 0.5x0.5 mm in host corneal bed lasting ≥6 weeks preoperatively
- Ocular or periocular malignancy
- Lid abnormalities that in the opinion of the investigator could confound the study results and these include clinically significant ectropion, lagophthalmos, cicatrization, entropion, and rosacea
- Neurotrophic cornea
- Monocular
- Uncontrolled glaucoma
- Glaucoma filtering devices or trabeculectomies
Where it is running
- Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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