Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)

Recruiting now

Conditions studied: Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome

In brief

Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings. The efficacy of most of these treatments on removal of inflammatory mediators is the main rationale behind the use of EBP in critically ill patients with multiorgan dysfunction. Nonetheless, there are still some doubts as to the clinical efficacy of bacterial toxins and cytokines removal and many clinical trials aiming at exploring the effect of EBP on long-term outcomes of septic patients have failed to demonstrate consistent results regarding 28 day- or hospital-mortality rates. The primary aim of this observational prospective web-based registry is to define the possible clusters of critically ill patients - treated with extracorporeal blood purification therapies worldwide - who are homogeneous regarding both clinical and treatment characteristics and seem to benefit the most from EBP.

Key facts

Study ID
NCT04580680
Run by
Careggi Hospital
People needed
1000
Starts
2020-11-01
Expected to finish
2025-09-30
Last updated by the study team
2025-02-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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