Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients

Completed · Phase 3 · Has a placebo group

Conditions studied: IgA Nephropathy

In brief

The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of iptacopan (LNP023) at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.

Key facts

Study ID: NCT04578834
Run by: Novartis Pharmaceuticals
People needed: 518
Starts: 2021-01-25
Expected to finish: 2025-09-19
Last updated by the study team: 2025-12-23

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male and female patients ≥ 18 years of age with an eGFR level and biopsy-confirmed IgA nephropathy as follows:
For patients eGFR* ≥ 45ml/min/1.73m2, a qualifying biopsy performed within the last 5 years is required.
For patients with eGFR* 30 to <45ml/min/1.73m2, a qualifying biopsy performed within 2 years with < 50% tubulointerstitial fibrosis is required.
For patients with eGFR* 20 to <30ml/min/1.73m2, a qualifying biopsy performed at any time.
In all cases, if a historical biopsy is not available, one may be performed during screening. *eGFR calculated using the CKD-EPI formula (or modified MDRD formula according to specific ethnic groups and local practice guidelines)
Proteinuria due to primary diagnosis of IgA nephropathy as assessed at screening by UPCR ≥1 g/g (113 mg/mmol) sampled from FMV or 24h urine collection, as well as at the completion of the run-in period by UPCR ≥1 g/g (113 mg/mmol) calculated as the (geometric) mean of two 24h urine collections obtained within 14 days of each other at baseline.
Vaccination against Neisseria meningitidis and Streptococcus pneumoniae infection is required prior to the start of study treatment. If the patient has not been previously vaccinated, or if a booster is required, vaccine should be given according to local regulations at least 2 weeks prior to first study drug administration. If study treatment has to start earlier than 2 weeks post vaccination, prophylactic antibiotic treatment should be initiated.
If not previously vaccinated, vaccination against Haemophilus influenzae infections should be given, if available and according to local regulations, at least 2 weeks prior to first study drug administration.
All patients must have been on supportive care including stable dose regimen of ACEi or ARB at either the locally approved maximal daily dose or the maximally tolerated dose (per investigators' judgment) for approximately 90 days before first study drug administration. In addition, if patients are taking diuretics, other antihypertensive medication, or other background medication for IgAN, the doses should also be stabilized for approximately 90 days prior to the first dosing of study treatment.

You may not qualify if…

Any secondary IgAN as defined by the investigator; secondary IgAN can be associated with cirrhosis, celiac disease, Human Immunodeficiency Virus (HIV) infection, dermatitis herpetiformis, seronegative arthritis, small-cell carcinoma, lymphoma, disseminated tuberculosis, bronchiolitis obliterans, and inflammatory bowel disease, familial mediterranean fever, etc.
Sitting office SBP >140 mmHg or DBP >90 mmHg at the randomization visit
Patients previously treated with immunosuppressive or other immunomodulatory agents such as but not limited to cyclophosphamide, rituximab, infliximab, eculizumab, canakinumab, mycophenolate mofetil (MMF) or mycophenolate sodium (MPS), cyclosporine, tacrolimus, sirolimus, everolimus, or systemic corticosteroids exposure (>7.5 mg/d prednisone/prednisolone equivalent) within 90 days (or 180 days for rituximab) prior to first study drug administration. Participants previously or currently treated with oral budesonide. Participants treated with endothelin (receptor) antagonists within 90 days prior to first study drug administration.
Prior use of iptacopan (LNP023) or prior enrollment in any other LNP023 clinical trial where study drug was taken, including matching placebo
History of recurrent invasive infections caused by encapsulated organisms, such as meningococcus and pneumococcus.
Active systemic bacterial, viral (including COVID-19) or fungal infection within 14 days prior to study drug administration.
Other protocol-defined inclusion/exclusion criteria may apply.

Where it is running

AKDHC Medical Research ServicesLLC — Phoenix, Arizona, United States
UCLA Medical Center — Los Angeles, California, United States
Kaiser Permanente — San Diego, California, United States
North America Research Institute — San Dimas, California, United States
University of Colorado Anschutz — Aurora, Colorado, United States
Nephrology Associates PA — Newark, Delaware, United States
Boise Kidney and Hypertension — Boise, Idaho, United States
CaRe Research — Chubbuck, Idaho, United States
Nep Assoc of Northern Illinois — Hinsdale, Illinois, United States
Renal Associates of Baton Rouge — Baton Rouge, Louisiana, United States
Johns Hopkins Hospital — Baltimore, Maryland, United States
Brigham and Womens Hosp Harvard Med School — Boston, Massachusetts, United States
University of Michigan — Ann Arbor, Michigan, United States
Mayo Clinic Rochester — Rochester, Minnesota, United States
Clin Rsrch Consult a JCCT Company — Kansas City, Missouri, United States
DaVita Clinical Research — Las Vegas, Nevada, United States
New Jersey Kidney Care — Jersey City, New Jersey, United States
Columbia University Irving Medical — New York, New York, United States
Dallas Renal Group — Dallas, Texas, United States
Prolato Clinical Research Center — Houston, Texas, United States
Univ of Washington Medi Cen — Seattle, Washington, United States
Novartis Investigative Site — Córdoba, Córdoba Province, Argentina
Novartis Investigative Site — Córdoba, Córdoba Province, Argentina
Novartis Investigative Site — CABA, Argentina
AZ Kidney Dise and Hypertension Ctr — Glendale, Arizona, United States

Full record on ClinicalTrials.gov

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