Unruptured Cerebral Aneurysm: Prediction of Evolution

Recruiting now

Conditions studied: Unruptured Intracranial Aneurysm

In brief

The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.

Key facts

Study ID

NCT04578808

Run by

Nantes University Hospital

People needed

1000

Starts

2019-08-19

Expected to finish

2031-03-15

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject carrying unruptured, asymptomatic and untreated typical IA of bifurcation, measured on conventional imaging (MRI, CTA or DSA) between 3 and 7 mm of larger diameter.
• Ability to be followed-up during 3 years decided in consensus multidisciplinary gathering.
• Age > 18 years old.

You may not qualify if…

• A failure to obtain informed consent
• Contraindications for undergoing an MRI scan include : (heart pacemaker, a metallic foreign body (metal sliver) in their eye, or aneurysm clip in their brain, severe claustrophobia)
• Contraindications for a gadolinium contrast medium injection (:eGFR below 30 mL/min/1.73 m2, Previous or pre-existing nephrogenic systemic fibrosis, Previous anaphylactic/anaphylactoid reaction to gadolinium containing contrast agent, Acutely deteriorating renal function, Pregnancy and breast-feeding)
• A mycotic, fusiform-shaped, or dissecting IA, an IA in relation with an arteriovenous malformation
• A family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan's syndrom, fibromuscular dysplasia, or Moya Moya disease
• Intra-cavernous UIA because the sinus cavernous that is fulfilled with venous blood precluded a reliable assessment of aneurysmal wall enhancement (AWE)

Where it is running

• Clairval's Hospital — Marseille, Bouches-du-Rhône, France (enrolling)
• Brest University Hospital — Brest, Finistère, France (enrolling)
• Bordeaux University Hospital — Bordeaux, Gironde, France (enrolling)
• Toulouse University Hospital — Toulouse, Haute-Garonne, France (enrolling)
• Limoges University Hospital — Limoges, Haute-Vienne, France (enrolling)
• Rennes University Hospital — Rennes, Ille-et-Vilaine, France (enrolling)
• Tours University Hospital — Tours, Indre-et-Loire, France (enrolling)
• Nantes University Hospital — Nantes, Loire-Atlantique, France (enrolling)
• Angers University Hospital — Angers, Maine et Loire, France (enrolling)
• Hôpital Foch — Suresnes, France (enrolling)
• St Anne HIA — Toulon, France (enrolling)
• Ste Anne's Hospital — Paris, Île-de-France Region, France (enrolling)
• Nancy University Hospital — Nancy, Meurthe-et-Moselle, France (enrolling)
• AP-HP La Pitié-Salpêtrière Hospital — Paris, Paris, France (enrolling)
• AP-HP Le Kremlin Bicêtre Hospital — Paris, Paris, France (enrolling)
• Rostchild Foundation Hospital — Paris, Paris, France (enrolling)
• Rouen University Hospital — Rouen, Seine-Maritime, France (enrolling)
• Amiens University Hospital — Amiens, Somme, France (enrolling)
• Creteil University Hospital — Créteil, Val-de-Marne, France (enrolling)
• CHU de Besançon — Besançon, France (enrolling)
• CHU de Caen — Caen, France (enrolling)
• CHU de Clermont Ferrand — Clermont-Ferrand, France (enrolling)
• CHU Dijon — Dijon, France (enrolling)
• CHU de Poitiers — Poitiers, France (enrolling)
• CHU de saint Etienne — Saint-Etienne, France (enrolling)

Full record on ClinicalTrials.gov

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