Assessment of Different Modified POEM for Achalasia

Recruiting now · Not applicable

Conditions studied: Esophageal Achalasia

In brief

The aims of this study is to compare the efficacy and safety of conventional myotomy (circular myotomy) and modified myotomy (full-thickness myotomy) in the treatment of achalasia patients.

Key facts

Study ID

NCT04578769

Run by

Peking Union Medical College Hospital

People needed

52

Starts

2020-09-02

Expected to finish

2026-05-30

Last updated by the study team

2025-12-10

Who can join

Age: 14 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosed as achalasia type I or II according to the Chicago Classification Version 4.0, with an Eckardt score >3
• Their age is ≥14years and ≤70 years
• Able to give written consent

You may not qualify if…

• undergone previous surgical treatments
• had contra-indication to general anesthesia
• previous surgery of the mediastinum, stomach, or esophagus;
• Pregnant or lactating female
• type III achalasia
• current alcohol or drug addiction, mental retardation, severe congenital or acquired coagulopathy (international normalized ratio >1.6)
• hepatic cirrhosis with or without portal hypertension, eosinophilic esophagitis (biopsies were performed at index endoscopy), or confirmed Barrett's esophagus
• esophageal diverticula or hiatal hernia based on findings from the index barium esophagram, or other conditions that the investigator believed not appropriate for POEM procedure

Where it is running

• Department of Gastroenterology, Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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