Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Recruiting now
Conditions studied: Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure, Non-Cirrhotic Portal Hypertension
In brief
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.
Key facts
- Study ID
- NCT04578301
- Run by
- University Hospital, Bonn
- People needed
- 200
- Starts
- 2020-09-22
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2022-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female adult (≥18 years) patient
- With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
- Or Non-cirrhotic portal hypertension
- Non-pregnant, non-lactating females
- Ability to understand the patient information and to personally sign and date the informed consent to participate in the study
- The patient is co-operative and available for the entire study
- Provided written informed consent
- Indication for surgical intervention
You may not qualify if…
- Pregnant or lactating females
- Patients undergoing surgery as form of palliative cancer therapy
- Presence or history of severe extra-hepatic diseases
- HIV-positive patients
- Previous liver or other transplantation
- Patients with acute or subacute liver failure without underlying cirrhosis
- Patients who decline to participate
- Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)
Where it is running
- University Hospital Bonn — Bonn, Germany (enrolling)
Full record on ClinicalTrials.gov
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