Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
Completed
Conditions studied: Sepsis, Shock, Septic
In brief
Lipids and lipoproteins (cholesterol and lipid metabolites) are present in sepsis and are highly biologically active regulators of inflammation, but currently the changes in lipid and lipoprotein homeostasis during sepsis are not well understood. This project will investigate the changes in lipid and lipoprotein function, oxidation, metabolites, and changes in gene expression to further our understanding of dysregulated lipid and lipoprotein metabolism in sepsis. We will analyze a bank of samples and make associations with important clinical outcomes (early death, chronic critical illness and sepsis recidivism) as supported by our published work, and will confirm our findings in a small prospective cohort of sepsis patients.
Key facts
- Study ID
- NCT04576819
- Run by
- University of Florida
- People needed
- 58
- Starts
- 2020-11-20
- Expected to finish
- 2023-04-01
- Last updated by the study team
- 2024-06-21
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients meeting the Sepsis-3 definition of sepsis or septic shock
- Treatment with an institutional, evidence-based guideline management bundle for sepsis within 24 hrs of sepsis recognition
- Sequential organ failure assessment (SOFA) score will be used for organ failure assessment.
You may not qualify if…
- a) alternative/confounding diagnosis causing shock (e.g., myocardial infarction or pulmonary embolus)
- b) uncontrollable source of sepsis (e.g., irreversible disease state such as unresectable dead bowel)
- c) advanced directives limiting resuscitative efforts
- d) organ transplant recipient on immunosuppressive agents
- e) known pregnancy
- f) inability to obtain informed consent
- g) HIV/AIDS with CD4 count < 200, h) absolute neutrophil count < 500. These criteria are justified by numerous prior studies.
Where it is running
- University of Florida — Jacksonville, Florida, United States
Full record on ClinicalTrials.gov
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