CRISIS2: A Phase 2 Study of the Safety and Antiviral Activity of Brequinar in Non-hospitalized Pts With COVID-19

Completed · Phase 2 · Has a placebo group

Conditions studied: COVID-19 Infection

In brief

This study will assess the efficacy and safety of DHODHi (brequinar) as an antiviral via 5 days of treatment of participants with positive COVID-19 and at least one symptom of COVI019 in an out-patient setting. The study is multi-center, randomized, and placebo-controlled.

Key facts

Study ID

NCT04575038

Run by

Clear Creek Bio, Inc.

People needed

115

Starts

2020-11-19

Expected to finish

2021-04-28

Last updated by the study team

2022-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing and able to provide informed consent for the trial, written, electronic, verbal or other method deemed acceptable by the institution and IRB.
• 18 years of age or older.
• Laboratory-confirmed SARS-CoV-2 infection as determined by real time polymerase chain reaction (RT-PCR) or other FDA-approved commercial or public health assay.
• Out-patient (never hospitalized as an in-patient for COVID-19 or was evaluated/treated for COVID-19 only in the Emergency Room with a stay of < 24 hours)
• The effects of brequinar on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Men and women treated or enrolled on this protocol must also agree to use adequate contraception for the duration of study participation, and for 90 days after completion of brequinar administration.
• Male subjects must agree to refrain from sperm donation and female subjects must agree to refrain from ovum donation from initial study drug administration until 90 days after the last dose of brequinar.
• Must have at least one COVID-19 symptom including but not limited to fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, shortness of breath, dyspnea, anosmia, dysgeusia, or other symptom commonly associated with COVID-19 in the opinion of the investigator. Symptom onset must be ≤7 days prior to first dose. Subject must have one or more symptoms at first dose.
• Able to swallow capsules.

You may not qualify if…

• Any physical examination findings and/or history of any illness that, in the opinion of the study investigator, might confound the results of the study or pose an additional risk to the patient
• Nursing women or women of childbearing potential (WOCBP) with a positive pregnancy test
• Treatment with another DHODH inhibitor (e.g., leflunomide, teriflunomide) or other agents known to cause bone marrow suppression leading to thrombocytopenia
• Platelets ≤150,000 cell/mm3
• Hemoglobin < 10 gm/dL
• Absolute neutrophil count < 1500 cells/mm3
• Renal dysfunction, i.e., creatinine clearance < 30 mL/min
• AST or ALT > 2 x ULN, or total bilirubin > ULN. Gilbert's Syndrome is allowed.
• Bleeding disorders or blood loss requiring transfusion in the six weeks preceding enrollment
• Ongoing gastrointestinal ulcer, or gastrointestinal bleeding within 6 weeks of randomization.
• Chronic hepatitis B infection, active hepatitis C infection, active liver disease and/or cirrhosis per subject report.
• Heart failure, current uncontrolled cardiovascular disease, including unstable angina, uncontrolled arrhythmias, major adverse cardiac event within 6 months (e.g. stroke, myocardial infarction, hospitalization due to heart failure, or revascularization procedure).

Where it is running

• Central Alabama Research — Homewood, Alabama, United States
• Ark Clinical Research — Long Beach, California, United States
• Doral Medical Research — Doral, Florida, United States
• South Jersey Infectious Disease — Somers Point, New Jersey, United States
• Monroe Biomedical Research — Monroe, North Carolina, United States
• Wilmington Health — Wilmington, North Carolina, United States
• Remington-Davis, Inc. — Columbus, Ohio, United States
• Toledo Institute of Clinical Research — Toledo, Ohio, United States
• VitaLink - Gaffney — Gaffney, South Carolina, United States
• Self Regional Healthcare Research Center - Self Medical Group — Greenwood, South Carolina, United States
• VitaLink Research — Spartanburg, South Carolina, United States
• Clinical Trials Center of Middle Tennessee — Franklin, Tennessee, United States
• Centex Studies, Inc. - McAllen — McAllen, Texas, United States
• Synexus Clinical Research US, Inc. - Olympus Family Medicine — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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