Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Severe Post-stroke Hemiparesis

Stopped early · Not applicable · Has a placebo group

Conditions studied: Stroke, Hemiparesis

In brief

Individuals who experienced a stroke over one year ago will be randomly assigned to receive 1 of 4 different conditions of brain stimulation. All individuals will receive therapy of the hand and arm following the stimulation. This study will try to determine which brain stimulation condition leads to the greatest improvement in hand and arm function.

Key facts

Study ID

NCT04574973

Run by

University of Kentucky

People needed

4

Starts

2018-11-28

Expected to finish

2021-01-08

Last updated by the study team

2021-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 12 or more months post-stroke
• Inability to extend the affected metacarpophalangeal joints at least 10 degrees and the wrist 20 degrees

You may not qualify if…

• Addition or change in dosage of drugs known to exert detrimental effects on motor recovery within 3 month of enrollment
• Untreated depression
• History of multiple strokes
• Exclusion criteria for TMS evaluations:
• History of head injury with loss of consciousness
• History of severe alcohol or drug abuse, or psychiatric illness
• Positive pregnancy test or being of childbearing age and not using appropriate contraception
• Presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure and surgical clips in or near the brain
• Cardiac or neural pacemakers

Where it is running

• University of Kentucky at Cardinal Hill Rehabilitation Hospital — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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