Multi-Drug Resistant Organism (MDRO): Study of Highly Resistant Escherichia Coli

Completed

Conditions studied: E Coli Infection

In brief

This is a prospective, observational, multicenter, case-control study.

Key facts

Study ID

NCT04574596

Run by

Duke University

People needed

300

Starts

2020-11-12

Expected to finish

2021-06-01

Last updated by the study team

2021-07-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Positive monomicrobial blood culture for 3GCR-Ec (cases) or 3GCS-Ec (control)
• Hospitalized at the time of obtaining index blood culture OR in the emergency department at the time of obtaining index blood culture, if followed by hospitalization within 72 hours

You may not qualify if…

• Previously included in this study as either control or case subject
• Previous blood culture positive for E. coli during the current hospitalization
• In vitro non-susceptibility to any carbapenem tested in the local clinical microbiology laboratory
• Evidence of carbapenemase production in the E. coli isolate of interest as determined by the local clinical microbiology laboratory

Where it is running

• Harbor-University of California Los Angeles Medical Center — Torrance, California, United States
• University of Colorado Denver — Aurora, Colorado, United States
• Emory University — Atlanta, Georgia, United States
• Ochsner Medical Center — New Orleans, Louisiana, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• University of Michigan Health System — Ann Arbor, Michigan, United States
• Henry Ford Health System — Detroit, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Weill Cornell Medical College — New York, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Case Western Reserve University — Cleveland, Ohio, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• The University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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