Metabolomics of Obstructive Sleep Apnea

Completed

Conditions studied: Obstructive Sleep Apnea

In brief

This is an R01 funded project that focuses on the utility of metabolomics as a biomarker for OSA. Aims 1 and 3 leverages banked samples previously collected from subjects with and without OSA at the University of Pennsylvania and University of Iceland. Aim 2 is a prospective study that will collect serum samples from OSA subjects at the University of Pennsylvania and the University of Iceland.

Key facts

Study ID

NCT04572269

Run by

University of Pennsylvania

People needed

388

Starts

2020-09-29

Expected to finish

2025-09-12

Last updated by the study team

2026-05-14

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Male or female, aged 30-75 years old
• In good general health as evidenced by medical history and diagnosed with Obstructive Sleep Apnea (defined as AHI>5)
• Ability to use accelerometer, perform Type 2 sleep test at home and agree to use PAP treatment.
• For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.

You may not qualify if…

• Current use of PAP treatment or mandibular advancement device or INSPIRE device
• Presence of active cancer treatment or heart failure (ejection fraction <40%)
• Pregnancy or lactation
• Known allergic reactions to components of the plastic (used in PAP mask)
• Febrile illness within 2 weeks of signing consent
• Current drug or alcohol abuse
• Known diagnosis and treatment of diabetes because this will independently alter metabolomic results.
• Previously drawn laboratory Hemoglobin A1C above normal range (indicative of diabetes).

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Iceland — Reykjavik, Iceland

Full record on ClinicalTrials.gov

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