Prostate Imaging Using MRI +/- Contrast Enhancement
Running, not enrolling · Not applicable
Conditions studied: Prostate Cancer
In brief
This prospective clinical trial (PRostate Imaging using Mri +/- contrast Enhancement (PRIME)) aims to assess whether biparametric MRI (bpMRI) is non-inferior to multiparametric mpMRI (mpMRI) in the detection of clinically significant prostate cancer. This means that we are comparing MRI scans that requires injection of IV contrast (the current standard practice) versus MRI scans that can be performed without IV contrast in the detection of prostate cancer.
Key facts
- Study ID
- NCT04571840
- Run by
- University College, London
- People needed
- 500
- Starts
- 2022-03-22
- Expected to finish
- 2025-03-01
- Last updated by the study team
- 2024-09-23
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Men at least 18 years of age referred with clinical suspicion of prostate cancer
- Serum PSA ≤ 20ng/ml
- Fit to undergo all procedures listed in protocol
- Able to provide written informed consent
You may not qualify if…
- Prior prostate biopsy
- Prior treatment for prostate cancer
- Prior prostate MRI on a previous encounter
- Contraindication to MRI
- Contraindication to prostate biopsy
- Unfit to undergo any procedures listed in protocol
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
- NYU Langone — New York, New York, United States
- Icahn School of Medicine (Mount Sinai) — New York, New York, United States
- New York Presbyterian Hospital — New York, New York, United States
- Centro de Urologia — Buenos Aires, Argentina
- Monash University — Melbourne, Australia
- Peter MacCallum Cancer Centre — Melbourne E., Australia
- Ghent University Hospital — Ghent, Belgium
- Hospital Sírio-Libanês — São Paulo, Brazil
- Princess Margaret Cancer Centre — Toronto, Canada
- Herlev and Gentofte Hospital — Copenhagen, Denmark
- Helsinki University Hospital — Helsinki, Finland
- Bordeaux Pellegrin University Hospital — Bordeaux, France
- CHU Lille — Lille, France
- Sorbonne Université — Paris, France
- Heinrich Heine University Düsseldorf — Düsseldorf, Germany
- Essen University Hospital — Essen, Germany
- University Hospital Frankfurt — Frankfurt, Germany
- Martini Klinik — Hamburg, Germany
- San Raffaele Hospital — Milan, Italy
- Sapienza University — Rome, Italy
- San Giovanni Battista Hospital — Turin, Italy
- University Hospital of Udine — Udine, Italy
- Radboudumc — Nijmegen, Netherlands
- Tan Tock Seng Hospital — Novena, Singapore
Full record on ClinicalTrials.gov
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