Effect of NMN Supplementation on Organ System Biology

Completed · Not applicable · Has a placebo group

Conditions studied: Glucose Metabolism Disorders

In brief

The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic function observed in rodents applies to people.

Key facts

Study ID

NCT04571008

Run by

Washington University School of Medicine

People needed

56

Starts

2020-10-01

Expected to finish

2025-03-04

Last updated by the study team

2026-03-11

Who can join

Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI 25.0-50.0 kg/m²
• Prediabetes defined as fasting plasma glucose of ≥100 mg/dL, or HbA1C ≥5.7, or HOMA-IR ≥2.5.

You may not qualify if…

• Women who are still having menses
• Persons who take niacin, nicotinamide, or other vitamin B3-related supplementation and are not willing to discontinue supplementation for 3 weeks before medical screening and during the entire study period
• Persons who consume moderate-large amounts of caffeine daily (>2 cups of coffee or 8 oz caffeinated drinks per day) or consume less amounts of caffeine but believe withdrawal symptoms (e.g. headache) are likely if caffeine is stopped
• Unstable weight (>3% change during the last 2 months before entering the study)

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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