Fluoxetine to Reduce Hospitalization From COVID-19 Infection (FloR COVID-19)

Withdrawn before enrolling · Early Phase 1 · Has a placebo group

Conditions studied: Covid19

In brief

The current research is a pilot study to determine the feasibility of recruiting and retaining 40 participants diagnosed with COVID-19. The purpose is to observe the early use of fluoxetine (commonly known as Prozac) to reduce the severity of the COVID-19 illness. Fluoxetine is a drug that has been approved by the U.S. Food and Drug Administration (FDA) since 1987 for various mental health disorders.

Key facts

Study ID

NCT04570449

Run by

Milton S. Hershey Medical Center

People needed

0

Starts

2020-11-01

Expected to finish

2021-12-01

Last updated by the study team

2020-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English speaking participant
• 18 years of age or older
• able to give informed consent
• Tested positive for active SARS-CoV-2 infection and
• It's been less than 10 days since symptoms first appeared;
• Fever persists for longer than 24 hours without the use of fever reducing medications; and
• Experiencing other symptoms of COVID-19 as described by the CDC

You may not qualify if…

• Prisoner or institutionalized patient
• Unable to give informed consent
• Less than 18 years of age
• Hospitalization
• Active bleeding requiring blood products in past week
• Diagnosed with bipolar disorder and not on mood stabilizing medication
• Known allergy or hypersensitivity to fluoxetine
• Currently taking a monoamine oxidase inhibitor (MAOI)
• Currently taking an selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI)
• Outpatient and currently taking hydroxychloroquine
• Known pregnancy
• Breastfeeding
• Known prolonged QTc, such as congenital prolonged QTc syndromes

Where it is running

• Milton S. Hershey Medical Center Clinical Research Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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