Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer

Running, not enrolling

Conditions studied: Endometrial Cancer

In brief

The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.

Key facts

Study ID

NCT04569773

Run by

Memorial Sloan Kettering Cancer Center

People needed

43

Starts

2020-09-23

Expected to finish

2026-09-23

Last updated by the study team

2025-08-22

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women aged ≥ 18 and ≤ 50 years
• Premenopausal
• Endometrioid histological diagnosis
• Scheduled for surgical intervention at MSKCC
• FIGO grade 1-2, clinical stage I
• Disease confined to uterus, no clear evidence of deep (≥50%) myoinvasion on imaging (MRI preferred, ultrasound optional)
• Normal ovaries on preoperative imaging
• Able to provide informed consent
• English-speaking

You may not qualify if…

• Known Lynch syndrome
• Prior bilateral oophorectomy
• Personal history of hormone receptor-positive breast carcinoma
• Increased risk of ovarian cancer identified on the basis of family or personal history
• Women currently on hormonal contraception, letrozole, or tamoxifen may not opt-in to AMH
• Women who recently underwent ovarian stimulation within the past 3 months may not opt-in to AMH
• Women who have pituitary dysfunction (or any pituitary disorders) may not opt-in to AMH
• Women who completed chemotherapy within <12 months may not opt-in to AMH

Where it is running

• Hartford Healthcare (Data Collection) — Hartford, Connecticut, United States
• Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (All protocol activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (All protocol activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Cancer Center @ Suffolk (All protocol activities) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (All protocol activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center (All Study Activities) — New York, New York, United States
• Memorial Sloan Kettering Nassau (All protocol activities) — Rockville Centre, New York, United States

Full record on ClinicalTrials.gov

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