A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS)
Completed · Phase 3 · Has a placebo group
Conditions studied: Familial Chylomicronemia Syndrome
In brief
The purpose of the study was to evaluate the efficacy of olezarsen as compared to placebo on the percent change in fasting triglycerides (TG) from baseline.
Key facts
- Study ID
- NCT04568434
- Run by
- Ionis Pharmaceuticals, Inc.
- People needed
- 66
- Starts
- 2020-11-18
- Expected to finish
- 2023-10-17
- Last updated by the study team
- 2025-03-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Diabetes/Lipid Management & Research Center — Huntington Beach, California, United States
- University of California, San Francisco (UCSF) - Medical Center — San Francisco, California, United States
- Excel Medical Clinical Trials, LLC — Boca Raton, Florida, United States
- NorthShore University Health System — Evanston, Illinois, United States
- Advocate Health and Hospitals Corporation - Lutheran General Hospital — Park Ridge, Illinois, United States
- Ascension St. Vincent Cardiovascular Research Institute — Indianapolis, Indiana, United States
- University of Kansas Medical Center (KUMC) — Kansas City, Kansas, United States
- University of Michigan- Endocrinology & Metabolism — Ann Arbor, Michigan, United States
- New York University (NYU) Langone Medical Center — New York, New York, United States
- Columbia University Medical Center — New York, New York, United States
- Moses H. Cone Memorial Hospital — Greensboro, North Carolina, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Vanderbilt University — Nashville, Tennessee, United States
- University of Texas Southwestern — Dallas, Texas, United States
- Baylor College of Medicine — Houston, Texas, United States
- York Clinical Research LLC — Norfolk, Virginia, United States
- West Virginia University Heart and Vascular Institute — Morgantown, West Virginia, United States
- Ecogene-21 — Chicoutimi, Quebec, Canada
- Nathalie Saint-Pierre — Montreal, Quebec, Canada
- Clinique des Maladies Lipidiques de Quebec Inc. — Québec, Quebec, Canada
- Institute de Recherches Cliniques de Montreal — Montreal, Canada
- Hôpital Louis Pradel - HCL — Bron, France
- CHU Dijon - Bocage — Dijon, France
- Assistance Publique - Hopitaux de Marseille — Marseille, France
- ASST Grande Ospedale Metropolitano Niguarda — Milan, Italy
Full record on ClinicalTrials.gov
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