Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

Running, not enrolling

Conditions studied: TBI (Traumatic Brain Injury)

In brief

BioBOOST is a multicenter, observational study of the effect of derangements in brain physiologic parameters on brain injury biomarker levels in patients with severe traumatic brain injury.

Key facts

Study ID

NCT04565119

Run by

University of Pennsylvania

People needed

300

Starts

2020-12-20

Expected to finish

2027-12-31

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled in BOOST-3 (this is an ancillary study to the BOOST-3 trial)
• BOOST-3 participant is enrolled at a BioBOOST site
• Able to maintain initial blood sample within 24 hours of injury
• Provide proxy informed consent

You may not qualify if…

• Profoundly anemic (subjects who are profoundly anemic require blood transfusion)
• Age less than 18 years

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States
• Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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