Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure

Completed

Conditions studied: Fuchs Dystrophy

In brief

This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease. We are trying to understand if the decrease in estrogen levels in post-menopausal women may be a reason why FECD is seen more often in women than men.

Key facts

Study ID

NCT04564378

Run by

State University of New York at Buffalo

People needed

43

Starts

2018-01-17

Expected to finish

2023-09-01

Last updated by the study team

2024-10-01

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals with FECD grade 1-2/7 (mild) or 5-6/7 (severe) in one or both eyes
• Age ≥ 55
• Phakic and pseudophakic individuals will be included. Pseudophakic patients must have evidence of routine cataract surgery (posterior chamber intraocular lens in-the-bag without clinical evidence of damage to any intraocular structures).

You may not qualify if…

• Females are excluded if not post-menopause.
• Pseudophakic patients with a history of complex cataract surgery or other intraocular surgery (e.g. have an anterior chamber lens, sulcus lens, or poorly positioned posterior chamber lens, aphakia, iris damage, glaucoma surgery) will be excluded due to risk of iatrogenic damage to the corneal endothelium.

Where it is running

• The Ira G. Ross Eye Institute — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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